Alan D D'Andrea Selected Research

Fanconi Anemia (Fanconi's Anemia)

1/2020	Biomarker-Guided Development of DNA Repair Inhibitors.
3/2019	The Fanconi Anemia Pathway in Cancer.
1/2018	A senataxin-associated exonuclease SAN1 is required for resistance to DNA interstrand cross-links.
4/2015	RNF4-mediated polyubiquitination regulates the Fanconi anemia/BRCA pathway.
12/2014	Ubiquitin recognition by FAAP20 expands the complex interface beyond the canonical UBZ domain.
3/2014	The carboxyl terminus of FANCE recruits FANCD2 to the Fanconi Anemia (FA) E3 ligase complex to promote the FA DNA repair pathway.
11/2013	Inactivation of Uaf1 causes defective homologous recombination and early embryonic lethality in mice.
1/2013	Proteasome inhibitors block DNA repair and radiosensitize non-small cell lung cancer.
7/2012	Regulation of DNA cross-link repair by the Fanconi anemia/BRCA pathway.
4/2012	Non-specific chemical inhibition of the Fanconi anemia pathway sensitizes cancer cells to cisplatin.

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Alan D D'Andrea Research Topics

Disease

61	Neoplasms (Cancer) 01/2022 - 07/2002
51	Fanconi Anemia (Fanconi's Anemia) 01/2020 - 05/2002
15	Hypersensitivity (Allergy) 12/2014 - 07/2002
14	Ovarian Neoplasms (Ovarian Cancer) 01/2022 - 07/2003
11	Genomic Instability 11/2018 - 01/2009
8	Chromosomal Instability (Chromosome Stability) 11/2013 - 01/2003
6	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/2021 - 08/2009
6	DNA Repair-Deficiency Disorders (Chromosome Instability Syndromes) 10/2019 - 06/2006
6	Breast Neoplasms (Breast Cancer) 10/2019 - 05/2003
6	Bone Marrow Failure Disorders 03/2019 - 01/2003
6	Chromosome Breakage 01/2019 - 12/2002
5	Complementation Group D1 Fanconi Anemia 06/2006 - 05/2003
4	Congenital Abnormalities (Deformity) 03/2019 - 01/2003
3	Pancreatic Neoplasms (Pancreatic Cancer) 12/2021 - 04/2013
3	Ataxia Telangiectasia (Louis Bar Syndrome) 01/2020 - 12/2002
3	Inborn Genetic Diseases (Disease, Hereditary) 03/2019 - 06/2006
3	Anemia 02/2017 - 07/2003
3	Chromosome Aberrations (Chromosome Abnormalities) 06/2008 - 05/2003
3	Aplastic Anemia (Anemia, Hypoplastic) 06/2006 - 10/2002
2	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/2021 - 12/2010
2	Squamous Cell Carcinoma of Head and Neck 07/2019 - 08/2011
2	Ovarian Epithelial Carcinoma 01/2019 - 02/2015
2	Fanconi Syndrome (Syndrome, Fanconi) 02/2017 - 07/2003
2	Triple Negative Breast Neoplasms 11/2016 - 12/2010
2	Carcinoma (Carcinomatosis) 03/2016 - 10/2013
2	Leukemia 12/2013 - 06/2006
2	Bloom Syndrome 11/2010 - 12/2009
1	Myelodysplastic Syndromes (Myelodysplastic Syndrome) 01/2021
1	Pneumonia (Pneumonitis) 01/2020
1	Disease Progression 01/2020
1	Sepsis (Septicemia) 01/2020
1	Urinary Bladder Neoplasms (Bladder Cancer) 01/2019
1	Nausea 01/2019
1	Squamous Cell Carcinoma (Epidermoid Carcinoma) 06/2017
1	Microsatellite Instability 01/2017
1	Colorectal Neoplasms (Colorectal Cancer) 11/2016
1	Mantle-Cell Lymphoma (Lymphoma, Mantle Cell) 11/2016
1	Radiation Pneumonitis 04/2016
1	Melanoma (Melanoma, Malignant) 03/2016
1	Endometrial Neoplasms (Endometrial Cancer) 12/2015

Drug/Important Bio-Agent (IBA)

43	DNA (Deoxyribonucleic Acid)IBA 10/2019 - 12/2002
32	Proteins (Proteins, Gene)FDA Link 01/2020 - 05/2002
18	Poly(ADP-ribose) Polymerase InhibitorsIBA 12/2021 - 12/2010
13	Biomarkers (Surrogate Marker)IBA 01/2022 - 08/2006
13	Mitomycin (Mitomycin-C)FDA LinkGeneric 12/2011 - 07/2002
8	PlatinumIBA 12/2021 - 08/2011
8	Cisplatin (Platino)FDA LinkGeneric 10/2019 - 05/2003
7	Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA 01/2020 - 12/2010
7	Deubiquitinating EnzymesIBA 12/2018 - 02/2005
7	A-Form DNA (A-DNA)IBA 04/2015 - 04/2006
5	Immune Checkpoint InhibitorsIBA 01/2020 - 12/2015
5	Pharmaceutical PreparationsIBA 07/2019 - 08/2006
5	UbiquitinIBA 12/2014 - 06/2006
4	olaparibIBA 12/2021 - 01/2019
4	Small Interfering RNA (siRNA)IBA 11/2013 - 08/2004
4	ChromatinIBA 11/2008 - 07/2004
3	prexasertibIBA 01/2021 - 10/2019
3	Phosphotransferases (Kinase)IBA 01/2020 - 12/2002
3	Messenger RNA (mRNA)IBA 01/2020 - 01/2016
3	1,2- di- (4- sulfamidophenyl)- 4- butylpyrazolidine- 3,5- dione (DSB)IBA 01/2016 - 11/2008
3	Proteasome InhibitorsIBA 11/2013 - 04/2012
3	Proliferating Cell Nuclear Antigen (PCNA)IBA 01/2012 - 04/2010
2	Gemcitabine FDA Link 01/2021 - 01/2020
2	berzosertibIBA 01/2021 - 01/2020
2	AldehydesIBA 01/2017 - 11/2012
2	Platinum Compounds (Compounds, Platinum)IBA 01/2016 - 04/2012
2	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA 03/2014 - 09/2006
2	Transcription Factors (Transcription Factor)IBA 12/2013 - 01/2011
2	Bortezomib (Velcade)FDA Link 11/2013 - 04/2012
2	Carboplatin (JM8)FDA LinkGeneric 04/2013 - 04/2012
2	Proteasome Endopeptidase Complex (Proteasome)IBA 01/2013 - 04/2012
2	Ligases (Synthetase)IBA 08/2006 - 06/2006
2	Fanconi Anemia Complementation Group D2 ProteinIBA 04/2006 - 12/2002
1	lysophosphatidic acidIBA 01/2022
1	LipidsIBA 01/2022
1	Interferon Type IIBA 01/2022
1	EnzymesIBA 01/2022
1	Phospholipids (Phosphatides)FDA LinkGeneric 01/2022
1	DNA Polymerase thetaIBA 01/2021
1	Novobiocin (Streptonivicin)FDA Link 01/2021
1	CohesinsIBA 01/2021
1	Anti-Bacterial Agents (Antibiotics)IBA 01/2021
1	Phosphoric Monoester Hydrolases (Phosphatases)IBA 11/2020
1	Checkpoint Kinase 1IBA 11/2020
1	pembrolizumabIBA 01/2020
1	niraparibIBA 01/2020
1	AlpelisibIBA 01/2019
1	Alanine Transaminase (SGPT)IBA 01/2019
1	BRCA2 ProteinIBA 01/2017
1	dinaciclibIBA 11/2016
1	Cyclin-Dependent Kinases (cdk Proteins)IBA 11/2016
1	Cyclin D1IBA 11/2016
1	Ubiquitin-Specific ProteasesIBA 11/2016
1	Protein Isoforms (Isoforms)IBA 01/2016
1	Alanine (L-Alanine)FDA Link 12/2014

Therapy/Procedure

18	Therapeutics 01/2022 - 12/2010
12	Drug Therapy (Chemotherapy) 12/2021 - 04/2006
6	Radiotherapy 07/2019 - 08/2011
3	Immunotherapy 01/2022 - 12/2015
1	Chemoradiotherapy 06/2017